Publications

Conference abstracts

Targeting Muco-Obstructive Lesions to Redefine COPD Treatment
Pelaseyed T.
COPD Drug Delevelopment Summit 2026

A γ-carboxyglutamate polymer detaches airway mucus and restores functional airway patency in a murine model of muco-obstructive lung disease
Ermund A, Recktenwald C, Trillo-Muyo S, Pelaseyed T, Hansson GC.
Poster presentation PA1476. European Respiratory Society Conference 2026

Publications

Structure of the MUC5AC VWD3 assembly responsible for the formation of net-like mucin polymers
Trillo-Muyo S, Ermund A, Hansson GC.
EMBO Rep. 2025 Mar;26(6):1457-1471. doi: 10.1038/s44319-025-00395-8. PMID: 40016425

The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based cross-linking
Recktenwald CV, Karlsson G, Garcia-Bonete MJ, Katona G, Jensen M, Lymer R, Bäckström M, Johansson MEV, Hansson GC, Trillo-Muyo S.
Cell Rep. 2024 May 28;43(5):114207. doi: 10.1016/j.celrep.2024.114207. PMID: 38733585

The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins
Gallego P, Garcia-Bonete MJ, Trillo-Muyo S, Recktenwald CV, Johansson MEV, Hansson GC.
Nat Commun. 2023 Apr 8;14(1):1969. doi: 10.1038/s41467-023-37666-8. PMID: 37031240

Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets
Rodriguez-Piñeiro AM, Jaudas F, Klymiuk N, Bähr A, Hansson GC, Ermund A.
Respir Res. 2023 Mar 16;24(1):83. doi: 10.1186/s12931-023-02381-x. PMID: 36927357

Mucus threads from surface goblet cells clear particles from the airways
Ermund A, Meiss LN, Dolan B, Jaudas F, Ewaldsson L, Bähr A, Klymiuk N, Hansson GC.
Respir Res. 2021 Nov 25;22(1):303. doi: 10.1186/s12931-021-01898-3. PMID: 34823518

New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition
Giorgetti M, Klymiuk N, Bähr A, Hemmerling M, Jinton L, Tarran R, Malmgren A, Åstrand A, Hansson GC, Ermund A.
Eur J Pharmacol. 2021 Aug 5;904:174123. doi: 10.1016/j.ejphar.2021.174123. PMID: 33974881

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin
Fakih D, Rodriguez-Piñeiro AM, Trillo-Muyo S, Evans CM, Ermund A, Hansson GC.
Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1270-L1279. doi: 10.1152/ajplung.00485.2019. PMID: 32348677

Assembly, Release, and Transport of Airway Mucins in Pigs and Humans
Ermund A, Trillo-Muyo S, Hansson GC.
Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S159-S163. doi: 10.1513/AnnalsATS.201804-238AW. PMID: 30431338

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs
Fernández-Blanco JA, Fakih D, Arike L, Rodríguez-Piñeiro AM, Martínez-Abad B, Skansebo E,
Jackson S, Root J, Singh D, McCrae C, Evans CM, Åstrand A, Ermund A, Hansson GC.
JCI Insight. 2018 Sep 6;3(17):e120994. doi: 10.1172/jci.insight.120994. PMID: 30185674

The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation
Ermund A, Meiss LN, Dolan B, Bähr A, Klymiuk N, Hansson GC.
Eur Respir J. 2018 Aug 30;52(2):1800457. doi: 10.1183/13993003.00457-2018. PMID: 29853489

Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers
Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC.
J Biol Chem. 2018 Apr 13;293(15):5746-5754. doi: 10.1074/jbc.RA117.001014. PMID: 29440393

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin
Ermund A, Meiss LN, Rodriguez-Pineiro AM, Bähr A, Nilsson HE, Trillo-Muyo S, Ridley C, Thornton DJ, Wine JJ, Hebert H, Klymiuk N, Hansson GC.
Biochem Biophys Res Commun. 2017 Oct 21;492(3):331-337. doi: 10.1016/j.bbrc.2017.08.113. PMID: 28859985

Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus
Ermund A, Meiss LN, Gustafsson JK, Hansson GC.
Eur J Pharmacol. 2015 Oct 5;764:109-117. doi: 10.1016/j.ejphar.2015.06.051. PMID: 26134505